Osmophobia as an early marker of migraine: a follow-up study in juvenile patients.

6533b7dcfe1ef96bd1272154

RESEARCH PRODUCT

Osmophobia as an early marker of migraine: a follow-up study in juvenile patients.

Vincenzo Raieli Michela Gatta Umberto Balottin Cristiano Termine D. Moscato Roberto Sangermani Giovanni Mazzotta Egle Perissinotto Stefano Sartori Elisabetta Tozzi D De Carlo Irene Toldo Pier Antonio Battistella Stefano Soriani Lara Dal Zotto Giorgio Zanchin L. N. Rossi A Vecchio

subject

Male children; follow-up; migraine without aura; Osmophobia; tension-type headache Pediatrics medicine.medical_specialty Adolescent Migraine Disorders Comorbidity Risk Assessment Phobic disorder Olfaction Disorders children Risk Factors osmophobia; juvenile primary headache; migraine without aura; tension-type headache Prevalence follow-up Humans Medicine Juvenile Sex Distribution Child business.industry Osmophobia Disease progression Follow up studies General Medicine medicine.disease Comorbidity tension-type headache Causality Osmophobia Early Diagnosis juvenile primary headache Italy Phobic Disorders Migraine migraine without aura Disease Progression Physical therapy Female Neurology (clinical)business Follow-Up Studies

description

Background: Osmophobia is frequent in children with migraine (20–35%) but can also occur in up to 14% of cases with tension-type headache (TTH). So far, the prognostic role of this symptom in children with primary headaches has never been evaluated. Methods: A longitudinal prospective study was conducted on 90 young patients with TTH (37 with osmophobia, 53 without osmophobia). We evaluated whether osmophobia could predict the diagnosis transformation from TTH to migraine after a 3-year follow-up. Results and Discussion: In our cases the rate of diagnosis change was significantly greater in cases with osmophobia (62%) than in those without (23%). Osmophobia persisted at a 3-year follow-up in the majority of our cases (85%) and it was found to be one of the major predictors for the development of migraine; other predictors of evolution to migraine were phonophobia, a probable rather than certain diagnosis of TTH and olfactory triggers (p < 0.05). Conclusion: Our data confirm that osmophobia has an important diagnostic and prognostic role in children with primary headaches and should be systematically investigated at diagnosis and during follow-up.

year	journal	country	edition	language
2012-01-01

10.1177/0333102412438975 http://hdl.handle.net/11391/1328907