Polifenoli un fenolskābes kā dziļās glikēšanas gala produktu veidošanās inhibitori in vitro

6533b7dcfe1ef96bd1272359

RESEARCH PRODUCT

Polifenoli un fenolskābes kā dziļās glikēšanas gala produktu veidošanās inhibitori in vitro

subject

rutīns AGE hlorogēnskābe gallu skābe Farmācija inhibīcija

description

Tiek uzskatīts, ka dziļās glikēšanas gala produktu (AGE) inhibitoriem ir terapeitisks potenciāls pacientiem, kuriem ir ar vecumu saistītas slimības, piemēram, diabēts, neirodeģenerācija, ateroskleroze. Šī bakalaura darba mērķis bija izpētīt fenolskābju galluskābes, hlorogēnskābes un polifenolu rutīna un kvercetīna ietekmi uz AGE veidošanos in vitro. AGE inhibīcijas īpašības tika pētītas in vitro, izmantojot divas modeļu sistēmas: liellopu seruma albumīns ar metilglioksālu un liellopu seruma albumīns ar glikozi. In vitro pētījumi liecināja par polifenolu un fenolskābju būtisku inhibējošu iedarbību uz AGE veidošanos. Visspēcīgākais glikācijas inhibitors bija rutīns. Visvājākais glikācijas inhibitors bija hlorogēnskābe.

year	journal	country	edition	language
2022-01-01

https://dspace.lu.lv/dspace/handle/7/59769

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