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RESEARCH PRODUCT
Histone post-translational modifications as potential therapeutic targets for pain management
Jose V. Torres-perezMuhammad Rizki FebriantoJahanzaib IrfanSimone Di GiovanniIstván Nagysubject
Farmacologiadorsal root ganglionPharmacological managementPainToxicologyBioinformaticsHistonesTissue damageHumansPain ManagementMedicinenociceptionPharmacology & PharmacyEpigeneticsspinal dorsal horn11 Medical and Health Sciencesneuropathic painPharmacologyepigeneticsbiologybusiness.industry06 Biological SciencesPain managementgene transcriptionNociceptionHistoneNeuropathic painPosttranslational modificationbiology.proteinbusinessProtein Processing Post-TranslationalGenèticadescription
Effective pharmacological management of pain associated with tissue pathology is an unmet medical need. Transcriptional modifications in nociceptive pathways are pivotal for the development and the maintenance of pain associated with tissue damage. Accumulating evidence has shown the importance of the epigenetic control of transcription in nociceptive pathways via histone post-translational modifications (PTMs). Hence, histone PTMs could be targets for novel effective analgesics. Here, we discuss the current understanding of histone PTMs in the modulation of gene expression affecting nociception and pain phenotypes following tissue injury. We also provide a critical view of the translational implications of preclinical models and discuss opportunities and challenges of targeting histone PTMs to relieve pain in clinically relevant tissue injuries.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-01-01 | Trends in Pharmacological Sciences |