6533b7dcfe1ef96bd12732d0
RESEARCH PRODUCT
Correlation between Regional Atp and Blood Flow in Tumors and Surrounding Normal Tissue
Wolfgang Mueller-klieserMarc DellianStefan WalentaAlwin E. Goetzsubject
CorrelationHigh-energy phosphatePathologymedicine.medical_specialtyMelanomamedicineNormal tissueDistribution (pharmacology)HamsterBlood flowBiologymedicine.diseasePathophysiologydescription
Various experimental and human tumors are characterized by a marked heterogeneity in the pathophysiologic micromilieu (1, 2). An inadequate and heterogeneous nutritional blood supply has been suggested to explain the non-uniform distribution of oxygen, pH, and high energy phosphates as it has been observed by many investigators (3, 4). Although there is a distinct understanding of the general interrelationships between these parameters (5), little is known about their actual regional correlation, which cannot be assessed by global measurements. With the autoradiographic method for measurement of blood flow (6, 7) and the metabolic imaging with ATP-induced bioluminescence (8, 9) it has become possible to evaluate the distribution of these physiological parameters in cryosections at an almost cellular level. In the present study both methods were combined to correlate regional blood flow with ATP values in the amelanotic hamster melanoma A-Mel-3. Locoregional measurements were obtained in mostly viable and mostly necrotic tumor areas, and in adjacent normal tissue as classified by histological investigation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-01-01 |