6533b7dcfe1ef96bd1273447
RESEARCH PRODUCT
Staging systems of hepatocellular carcinoma: A review of literature
Marcello MaidaEmanuele OrlandoCalogero CammàGiuseppe Cabibbosubject
Oncologymedicine.medical_specialtyAsiaCarcinoma HepatocellularTime FactorsMedical OncologyGastroenterologyInternal medicineBiomarkers TumorHumansMedicineTopic HighlightNeoplasm Stagingbusiness.industryIncidence (epidemiology)Liver NeoplasmsGastroenterologyExternal validationReproducibility of ResultsGeneral MedicinePrognosismedicine.diseasedigestive system diseasesEuropeNatural historyHepatocellular carcinomabusinessAlgorithmsdescription
Hepatocellular carcinoma (HCC) is a major health problem with a high incidence and mortality all over the world. Natural history of HCC is severe and extremely variable, and prognostic factors influencing outcomes are incompletely defined. Over time, many staging and scoring systems have been proposed for the classification and prognosis of patients with HCC. Currently, the non-ideal predictive performance of existing prognostic systems is secondary to their inherent limitations, as well as to a non-universal reproducibility and transportability of the results in different populations. New serological and histological markers are still under evaluation with promising results, but they require further evaluation and external validation. The aim of this review is to highlight the main tools for assessing the prognosis of HCC and the main concerns, pitfalls and warnings regarding its staging systems currently in use.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-11-01 | World Journal of Gastroenterology |