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RESEARCH PRODUCT
Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes.
Helgi B. SchiöthUlf GyllenstenJanis KlovinsJanis KlovinsJosefin A. JacobssonPernilla DanielssonClaude MarcusRobert FredrikssonVictoria Svenssonsubject
Adultmedicine.medical_specialtyendocrine system diseasesAdolescentmedicine.medical_treatmentBiophysicsAlpha-Ketoglutarate-Dependent Dioxygenase FTOSingle-nucleotide polymorphismBiochemistryFTO genePolymorphism Single NucleotideRisk AssessmentBody Mass IndexInsulin resistanceSex FactorsRisk FactorsInternal medicineDiabetes mellitusmedicinePrevalenceSNPHumansGenetic Predisposition to DiseaseObesitySex DistributionChildMolecular BiologySwedenbusiness.industryInsulinnutritional and metabolic diseasesGenetic VariationProteinspathological conditions signs and symptomsCell Biologymedicine.diseaseObesityEndocrinologyPhenotypeInsulin ResistancebusinessBody mass indexdescription
Recent studies have shown that SNPs in the FTO gene predispose to childhood and adult obesity. In this study, we examined the association between variants in FTO and KIAA1005, a gene that maps closely to FTO, and obesity, as well as obesity related traits among 450 well characterised severely obese children and 512 normal weight controls. FTO showed significant association with several obesity related traits while SNPs in KIAA1005 did not. When stratified by gender, the FTO variant rs9939609 showed association with obesity and BMI among girls (P = 0.006 and 0.004, respectively) but not among boys. Gender differences were also found in the associations of the FTO rs9939609 with obesity related traits such as insulin sensitivity and plasma glucose. This study suggests that FTO may have an important role for gender specific development of severe obesity and insulin resistance in children.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-04-01 | Biochemical and biophysical research communications |