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RESEARCH PRODUCT
Immunohistochemical expression of Skp2 protein in oral nevi and melanoma
Oslei Paes-de-almeidaAdalberto Mosqueda-taylorJorge-esquiche LeónWilson Delgado-azañeroBruno-augusto Benevenuto-de-andradeRoman Carlossubject
AdultMalePathologymedicine.medical_specialtyAdolescentLabeling indexOdontologíaYoung AdultUbiquitinmedicineSKP2HumansMelanomaNevusS-Phase Kinase-Associated ProteinsneoplasmsGeneral DentistryAgedOral Medicine and Pathologybiologybusiness.industryMelanomaMiddle Aged:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseImmunohistochemistry//purl.org/pe-repo/ocde/ford#3.02.14 [https]Ciencias de la saludOral melanomaoral nevistomatognathic diseasesOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASimmunohistochemistrybiology.proteinImmunohistochemistryResearch-ArticleFemaleMouth Neoplasmscell cycleSurgerySkp2Differential diagnosisbusinessdescription
Objective: The aim of this study was to analyze the immunohistochemical expression of Skp2 protein in 38 oral nevi and 11 primary oral melanomas. Study Design: Expression of this ubiquitin protein was evaluated by immunohistochemistry in 49 oral melanocytic lesions, including 38 intramucosal nevi and 11 primary oral melanomas. The labeling index (LI) was assessed considering the percentage of cells expressing nuclear positivity out of the total number of cells, counting 1000 cells per slide. Results: Skp2 protein was rarely expressed in intramucosal nevi, in contrast to oral melanomas, which showed high levels of this protein. Conclusion: These results indicate that Skp2 protein may play a role in the development and progression of oral melanomas, and it also could be useful as an immunohistochemical marker for differential diagnosis of oral benign and malignant melanocytic lesions. Key words:Oral melanoma, oral nevi, Skp2, cell cycle, immunohistochemistry.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-02-01 | Medicina Oral Patología Oral y Cirugia Bucal |