6533b7dcfe1ef96bd127351d

RESEARCH PRODUCT

PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data

G GulloV UnferCarlomagno GCatalano G.Alessandra Vassiliadis

subject

InfertilityGynecologymedicine.medical_specialtybusiness.industrymedicine.medical_treatmentPCOS InfertilityMetforminOvulation inductionPregnancy.medicine.diseaseSettore MED/40 - Ginecologia E OstetriciaMetforminmedicineOvulation inductionIn patientbusinessAdministration (government)medicine.drug

description

The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures. Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors. Metformin administration started 2 months before the ovulation induction. Alternatively a spontaneous menstruation it was induced by progestin. Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support was administrated. Results showed 100% of ovulatory cycles, 5 pregnancies and only 1 lost. Few side effects.

yearjournalcountryeditionlanguage
2014-07-01Giornale Italiano di Ostetricia e Ginecologia
https://doi.org/10.11138/giog/2014.36.4.443