6533b7ddfe1ef96bd1273d04
RESEARCH PRODUCT
Organometallic complexes with biological molecues, part 3.in vivo cytotoxicity of diorganotin (IV) chloro and triorganotin (IV) chloro derivatives of penicillin g on chromosomes ofaphanius fasciatus (pisces, cyprinodontiformes)
Lorenzo PelleritoA. PelleritoC. MansuetoAntonio GianguzzaFrancesco MaggioRoberto Vitturisubject
biologyStereochemistryChemistryMutagenBiological activityGeneral Chemistrybiology.organism_classificationmedicine.disease_causeChromosome aberrationStainingInorganic ChemistryIn vivomedicineCyprinodontiformesMitosisGenotoxicitydescription
In order to obtain a continuous source of mitotic metaphases, gill tissue of Aphaius fasciatus (Pisces, Cyprinodontiformes) has been successfully employed. Results gathered after exposure of fish to R2SnClpenG, R3SnClpenGNa, to the parents R2SnCl2, R3SnCl and to penGNa (penGNa = penicillinGNa; R = methyl, butyl and phenyl) suggest that both the parent organotin (IV) chloride and organotin (IV) chloropenG derivatives are toxic while penGNa exerts no significant toxic activity. Essentially, all of the chromosome abnormalities are classifiable as irregularly staining of chromosomes, breakages, side-arm bridges or pseudochiasmata.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-10-01 | Applied Organometallic Chemistry |