6533b7ddfe1ef96bd1273f34

RESEARCH PRODUCT

The effect of cancer on sperm DNA fragmentation as measured by the sperm chromatin dispersion test

José Luis FernándezNicolás GarridoRebeca SantisoMarcos Meseguer

subject

MaleInfertilityendocrine systemPregnancy Ratemedia_common.quotation_subjectPilot ProjectsFertilitySemenDNA FragmentationBiologyAndrologyPregnancyNeoplasmsmedicineHumansSperm Injections IntracytoplasmicFragmentation (cell biology)Infertility Malereproductive and urinary physiologySperm motilitymedia_commonCryopreservationSperm Counturogenital systemObstetrics and GynecologyCancermedicine.diseaseSpermatozoaSpermChromatinTreatment OutcomeReproductive MedicineSperm MotilityDNA fragmentationFemaleSemen Preservation

description

The percentage of spermatozoa with fragmented DNA from cancer patients before surgery, chemotherapy, or radiotherapy treatments was compared with infertile male patients in an assisted reproduction program and with sperm donors of proven fertility. The percentages of DNA fragmentation were 34.3% in cancer patients, 30.9% in infertile men whose partners did not become pregnant, 28.8% in men who partners became pregnant, and 10.8% in fertile sperm donors. The DNA fragmentation of sperm donors was statistically significantly lower compared the other groups. No statistically significant differences were found in the levels of DNA fragmentation when comparing cancer types, including those of testicular origin.

yearjournalcountryeditionlanguage
2008-07-01Fertility and Sterility
https://doi.org/10.1016/j.fertnstert.2007.06.026