6533b7ddfe1ef96bd1274869
RESEARCH PRODUCT
Labdane Diterpenoids from Marrubium globosum ssp. libanoticum
Maurizio BrunoDaniela RiganoNelly Apostolides ArnoldSergio RosselliFelice SenatoreFranco PiozziArmando GrassiaCarmen Formisanosubject
StereochemistryLEONURUSPharmaceutical SciencePharmacognosyAnalytical ChemistryLabdanechemistry.chemical_compoundDrug DiscoveryBotanyLebanonNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationFolk medicinePlants MedicinalMolecular StructurebiologyOrganic Chemistrybiology.organism_classificationTerpenoidComplementary and alternative medicinechemistryMolecular MedicineDiterpenesDiterpeneLactoneMarrubiumMarrubiumdescription
From the aerial parts of Marrubium globosum ssp. libanoticum, seven labdane diterpenoids were isolated. Three of them are new natural products [(13R)-9alpha,13alpha-epoxylabda-6beta(19),16(15)-diol dilactone (2), deacetylvitexilactone (7), marrulanic acid (8)], whereas the other four, namely, (13S)-9alpha,13alpha-epoxylabda-6beta(19),16(15)-diol dilactone (1), cyllenin A (3), 15-epi-cyllenin A (4), and marrulibanoside, are previously known compounds. The structures of 2, 7, and 8 were determined by spectroscopic and chemical methods.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-01-01 | Journal of Natural Products |