6533b7ddfe1ef96bd127512c
RESEARCH PRODUCT
Clinical results of EGFR-targeted therapies in advanced colorectal cancer
Giuseppe ColucciVittorio GebbiaFranco MorelliAntonio Maria GrimaldiLuigi ManzioneCarlo ArcaraEvaristo MaielloFrancesco Giulianisubject
OncologyCancer Researchmedicine.medical_specialtyChemotherapyCetuximabbusiness.industryColorectal cancermedicine.medical_treatmentCancermedicine.diseaseSurgeryTargeted therapyOncologyFOLFOXInternal medicineFOLFIRIMedicinePanitumumabbusinessmedicine.drugdescription
Abstract This paper is an updated review of the pre-clinical rationale and clinical results of new EGFR-targeted agents – cetuximab and panitumumab – employed in the management of advanced/ metastatic colorectal cancer. The addition of either biologic agent or last generation standard chemotherapy regimens – FOLFIRI and FOLFOX – has yielded better results as compared to those reported for chemotherapy alone. These results have been obtained without a significant increase in severe toxicity with the exception of skin side-effects.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2008-10-01 | European Journal of Cancer Supplements |