6533b7ddfe1ef96bd12752e1
RESEARCH PRODUCT
Recent advanced in bioactive systems containing pyrazole fused with a five membered heterocycle
Giuseppe DaidoneDemetrio RaffaFabiana PlesciaStella CascioferroBenedetta MaggioMaria Valeria RaimondiGabriella Cancemisubject
PharmacologyStereochemistryOrganic Chemistrypyrazole fused with a five membered heterocycle bioactive systemGeneral MedicinePyrazoleRing (chemistry)Settore CHIM/08 - Chimica Farmaceuticachemistry.chemical_compoundOxygen atomchemistryTherapeutic AreaDrug DiscoveryAnimalsHumansPyrazolesMoleculedescription
In this review we report the recent advances in bioactive system containing pyrazole fused with a five membered heterocycle, covering the time span of the last decade. All of them are represented around the common structure of the pyrazole ring fused with another five membered heterocycle containing the nitrogen, sulfur and oxygen atoms in all their possible combinations. The classification we have used is based in terms of the therapeutic area providing, when possible, some general conclusions on the targets and mechanisms of action as well as the structure-activity relationships of the molecules.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-06-01 |