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RESEARCH PRODUCT

A whole genome screen for linkage disequilibrium in multiple sclerosis performed in a continental Italian population

Marta MellaiGiuseppe SalemiAnna Maria RepiceEfrosini SetakisGiovanni RistoriFranca Rosa GueriniDomenico CaputoFrancesca De RobertisIda BiunnoMaurizio LeoneIsabella FerroStephen SawcerMaria LiguoriPaola NaldiGiancarlo ComiStefania CannoniGiovanni SavettieriLuigi M.e. GrimaldiGiulia MalferrariTiziana BiagioliRoberto BomprezziMaria TrojanoLuca MassacesiPatricia Momigliano-richiardiMarco SalvettiPaolo AridonSandra D'alfonsoAlastair CompstonPaolo LivreaCinzia GelleraLa Mantia LoredanaPasquale FerranteClara BalleriniClara MilaneseMara Giordano

subject

MaleLinkage disequilibriumMultiple SclerosisGenotypeInternational CooperationImmunologyBiologyGenomeLinkage DisequilibriumWhole genome linkage disequilibriumGene FrequencyGenotypemedicineHumansImmunology and AllergyGenetic Predisposition to DiseaseMultiple sclerosiGenetic TestingGenotypingAllele frequencyAllelesGenetic testingGeneticsmedicine.diagnostic_testGenome HumanRacial GroupsDNA poolMicrosatelliteSettore BIO/18 - GeneticaItalyNeurologyCase-Control StudiesMicrosatelliteHuman genomeFemaleSettore MED/26 - NeurologiaNeurology (clinical)Microsatellite Repeats

description

We have systematically screened the genome for evidence of linkage disequilibrium (LD) with multiple sclerosis (MS) by typing 6000 microsatellite markers in case-control and family based (AFBAC) cohorts from the Italian population. DNA pooling was used to reduce the genotyping effort involved. Four DNA pools were considered: cases (224 Italian MS patients), controls (231 healthy Italians), index (185 index cases from trio families) and parents (the 370 parents of the patient included in the Index pool), respectively. After refining analysis of the most promising 14 markers to emerge from this screening process, only marker D2S367 retained evidence for association. © 2003 Elsevier B.V. All rights reserved.

yearjournalcountryeditionlanguage
2003-01-01
10.1016/j.jneuroim.2003.08.020http://hdl.handle.net/10447/207738