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RESEARCH PRODUCT
Association between symptoms of depression, diabetes complications and vascular risk factors in four European cohorts of individuals with type 1 diabetes - InterDiane Consortium
Rasa VerkauskieneLinda ZaharenkoSabīne SkrebinskaLina RadzevicieneTomislav BulumKristina BlaslovJelizaveta SokolovskaLea DuvnjakCarol ForsblomCarol ForsblomValdis PiragsAila J. AholaEdita PrakapieneVinko RosoVita Rovitesubject
MaleEndocrinology Diabetes and MetabolismDISEASEDiabetic nephropathy0302 clinical medicineEndocrinologyRisk FactorsGLYCEMIC CONTROLSurveys and QuestionnairesPrevalence030212 general & internal medicineDepression (differential diagnoses)2. Zero hungerDepressionGeneral MedicineMiddle AgedMetabolic syndrome3. Good healthEuropeType 1 diabetesFemaleHEALTHAdultmedicine.medical_specialty030209 endocrinology & metabolismRETINOPATHYDiabetes Complications03 medical and health sciencesInternal medicineDiabetes mellitusInternal MedicinemedicineHumansVascular DiseasesType 1 diabetesbusiness.industry616.379-008.64 [udc]Beck Depression InventoryADULTSCAREmedicine.diseaseCross-Sectional StudiesDiabetes Mellitus Type 13121 General medicine internal medicine and other clinical medicineDepression ; Diabetes complications ; Metabolic syndrome ; Type 1 diabetesDiabetes mellitus type 1 ; psychology ; Depression ; Diabetes complications ; Metabolic syndrome ; Cross-sectional studiesSelf ReportMetabolic syndromebusinessBody mass indexMacedescription
Aims: To investigate the association between depressive symptomatology and health markers in type 1 diabetes. Methods: Four countries from the InterDiane Consortium had adopted the Finnish Diabetic Nephropathy Study protocol, including the Beck Depression Inventory (BDI). Associations between depression symptomatology, diabetes complications (diabetic nephropathy, proliferative retinopathy, major adverse cardiovascular events [MACE]) and vascular risk factors (metabolic syndrome, body mass index, glycaemic control) were investigated. Results: In a sample of 1046 participants (Croatia n = 99; Finland n = 314; Latvia n = 315; Lithuania n = 318), 13.4% displayed symptoms of depression (BDI score 16) with no statistically significant difference in the prevalence of depression among the cohorts. The highest rates of diabetic nephropathy (37.1%) and proliferative retinopathy (36.3%) were observed in Lithuania. The rates of MACE and metabolic syndrome were highest in Finland. In joint analyses, individuals exhibiting depression symptomatology had higher HbA(1c) (79 vs. 72 mmol/mol, p <0.001) and higher triglyceride concentration (1.67 vs. 1.28 mmol/l, p <0.001), than those without. In the multivariable model, BDI score was positively associated with the presence of diabetic nephropathy, proliferative retinopathy, MACE, and metabolic syndrome and its triglyceride component. Moreover, BDI score was positively associated with the number of metabolic syndrome components, triglyceride concentration, and HbA(1c). Conclusions: Comorbid depression should be considered a relevant factor explaining metabolic problems and vascular outcomes. Causality cannot be inferred from this crosssectional study. (c) 2020 Elsevier B.V. All rights reserved. Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-12-01 |