6533b7defe1ef96bd1275ebb
RESEARCH PRODUCT
Evoked otoacoustic emissions and pure tone threshold audiometry in patients receiving cisplatinum therapy.
H.j. SchmittP. GutjahrP.g. Zorowkasubject
AdultMalemedicine.medical_specialtyFunctional impairmentElectrodiagnosisAdolescentCochlear DiseasesOtoacoustic Emissions SpontaneousOtoacoustic emissionAudiologyNeoplasmsotorhinolaryngologic diseasesMedicineHumansIn patientChildHearing Disordersmedicine.diagnostic_testbusiness.industryPure toneGeneral MedicineOtorhinolaryngologyAcoustic StimulationChild PreschoolPediatrics Perinatology and Child HealthEvoked Potentials AuditoryAudiometry Pure-ToneFemalePure tone audiometryAudiometryCisplatinbusinessdescription
Eight children and young adults with cancer were evaluated serially using pure tone audiometry as well as registration of click-evoked otoacoustic emissions (EOAE) 1 day prior to therapy as well as after various numbers of doses of cisplatinum. A reduction of EOAE-amplitudes following cisplatinum therapy was observed in all patients. This reduction tended to recover after the end of cisplatinum administration. Since EOAE are believed to result from cochlear bio-mechanical processes, the reduced emissions are interpreted as signs of cochlear dysfunction. We conclude, that EOAE testing may be a simple, non-invasive method that may detect early, transient functional impairment of hearing due to ototoxic agents such as cisplatinum, even in children. Further controlled trials are needed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-01-01 | International journal of pediatric otorhinolaryngology |