The endocannabinoid system controls food intake via olfactory processes

6533b7defe1ef96bd1275f74

RESEARCH PRODUCT

The endocannabinoid system controls food intake via olfactory processes

Hans-christian Pape Theresa Wiesner Hirac Gurden Anna Chiarlone Aya Wadleigh Pierre-marie Lledo Luigi Bellocchio Guillaume Ferreira Federico Massa Danièle Verrier Claire Martin Manuel Guzmán Peggy Vincent Tiffany Desprez Gabriel Lepousez Astrid Cannich Leire Reguero Beat Lutz Pedro Grandes Sabine Ruehle Antoine Nissant Giovanni Marsicano Mounir Bendahmane Floortje Remmers Edgar Soria-gomez Isabelle Matias Carmelo Quarta

subject

Male Olfactory system MESH: Olfactory Perception Cannabinoid receptor MESH: Feedback Physiological [SDV]Life Sciences [q-bio]medicine.medical_treatment MESH: Cannabinoid Receptor Agonists MESH: Endocannabinoids MESH: Receptor Cannabinoid CB1 Synaptic Transmission MESH: Mice Knockout MESH: Eating Eating Mice Olfactory bulb Receptor Cannabinoid CB1 MESH: Animals Feedback Physiological Mice Knockout musculoskeletal neural and ocular physiology General Neuroscience digestive oral and skin physiology Olfactory Pathways Endocannabinoid system MESH: Feeding Behavior lipids (amino acids peptides and proteins)psychological phenomena and processes MESH: Olfactory Bulb Biology Inhibitory postsynaptic potential Glutamatergic MESH: Mice Inbred C57BL MESH: Synaptic Transmission medicine Animals MESH: Mice Cannabinoid Receptor Agonists Feeding Behavior Olfactory Perception MESH: Male Olfactory bulb Mice Inbred C57BL nervous system Odor Feeding behaviour Cannabinoid [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition Neuroscience MESH: Olfactory Pathways Endocannabinoids

description

Comment in Sensory systems: the hungry sense. [Nat Rev Neurosci. 2014] Inhaling: endocannabinoids and food intake. [Nat Neurosci. 2014]; International audience; Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.

year	journal	country	edition	language
2014-03-17	Nature Neuroscience

https://doi.org/10.1038/nn.3647