6533b7defe1ef96bd1276821

RESEARCH PRODUCT

Bis-1,2,4-triazolo[4,3-a:3′,4′-c]quinoxalines of pharmaceutical interest from 1,3-dipolar cycloaddition

Antonino LauriaGaetano DattoloAnna Maria AlmericoAnnalisa Guarcello

subject

Organic ChemistrySettore CHIM/06 - Chimica OrganicanitriliminesSettore CHIM/08 - Chimica FarmaceuticaBiochemistryCycloadditionchemistry.chemical_compoundQuinoxalinechemistryComputational chemistry13-dipolar cycloadditionquinoxalineDrug Discovery13-Dipolar cycloadditionOrganic chemistry

description

Abstract Various derivatives of the heterocyclic system 1,12,12a,12b-tetrahydrobis-1,2,4-triazolo[4,3-a:3′,4′-c]quinoxaline of pharmaceutical interest have been obtained by double site- and regio-selective 1,3-dipolar cycloaddition of arylnitrilimines to quinoxalines. No evidence for the formation of mono-adducts was obtained, at variance with literature reports. Specific studies to establish the exact stereochemistry of the bis-cycloadducts were undertaken.

yearjournalcountryeditionlanguage
2008-03-01Tetrahedron Letters
https://doi.org/10.1016/j.tetlet.2008.01.047