6533b81ffe1ef96bd12772cf
RESEARCH PRODUCT
Cross-reactivity of anti-ssDNA antibodies with heparan sulfate in patients with type I diabetes mellitus
Ferdinando MeliFrancesca CardellaE GiardinaBompiani GdGiovanna SeddioGiovanni TrioloGiovanna Scarantinosubject
medicine.medical_specialtyRenal glomerulusEndocrinology Diabetes and MetabolismDNA Single-StrandedEnzyme-Linked Immunosorbent AssayPerlecanCross ReactionsBiologyGlycosaminoglycanchemistry.chemical_compoundInternal medicinemedicineInternal MedicineHumansChildGlycosaminoglycansBasement membraneGlomerular basement membraneHeparan sulfateBlood proteinsMolecular biologyDiabetes Mellitus Type 1Endocrinologymedicine.anatomical_structurechemistryImmunoglobulin Gbiology.proteinHeparitin SulfateAntibodydescription
Anti-single-stranded–DNA antibodies cross-reactive with heparan sulfate were detected in serums of patients with type I (insulin-dependent) diabetes mellitus. The results suggested that heparan sulfate, the major glycosaminoglycan constituent of the glomerular basement membrane, may serve as a target antigen in vivo for cross-reactive anti-DNA antibodies. These polyreactive antibodies, directed toward repeating negatively charged units, may neutralize the heparan sulfate–associated polyanionic sites in the glomerulus, leading to an abnormal permeability of anionic plasma proteins.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-06-01 |