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RESEARCH PRODUCT

Identification of High-Risk Atypical Meningiomas According to Semantic and Radiomic Features

Harald KrenzlinNaureen KericClemens SommerPetra LeukelMarc A. BrockmannMirjam RenovanzFlorian RingelAndrea KronfeldDarius KalasauskasElena Kurz

subject

Cancer Researchmedicine.medical_specialtyMultivariate analysisTumor resectionlcsh:RC254-282survivalArticleWorld healthResection03 medical and health sciences0302 clinical medicineatypical meningiomamedicineUnivariate analysisbusiness.industryHazard ratiopredictionOdds ratiolcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensConfidence intervalOncologyradiomics030220 oncology & carcinogenesisRadiologybusiness030217 neurology & neurosurgery

description

Up to 60% of atypical meningiomas (World Health Organization (WHO) grade II) reoccur within 5 years after resection. However, no clear radiological criteria exist to identify tumors with higher risk of relapse. In this study, we aimed to assess the association of certain radiomic and semantic features of atypical meningiomas in MRI with tumor recurrence. We identified patients operated on primary atypical meningiomas in our department from 2007 to 2017. An analysis of 13 quantitatively defined radiomic and 11 qualitatively defined semantic criteria was performed based on preoperative MRI scans. Imaging characteristics were assessed along with clinical and survival data. The analysis included 76 patients (59% women, mean age 59 years). Complete tumor resection was achieved in 65 (86%) cases, and tumor relapse occurred in 17 (22%) cases. Mean follow-up time was 41.6 (range 3&ndash

yearjournalcountryeditionlanguage
2020-10-01Cancers
https://doi.org/10.3390/cancers12102942