6533b81ffe1ef96bd12781f2
RESEARCH PRODUCT
Isolation of HTLV III/LAV from drug addicts in Palermo.
Romano NPortera MVitale FRusso Alesi DTorregrossa M VPerrera Gsubject
HTLIII/LAV PalermoAIDS-Related Complex/microbiologyMaleRiskAIDS-Related ComplexSubstance-Related DisordersHIVHumansFemaleLymphocytesisolation HTLIII/LAVSettore MED/42 - Igiene Generale E ApplicataSicilydescription
The new human retroviruses HTLV III/LAV, implicated as the causative agent of AIDS, have been isolated from peripheral blood lymphocytes of 5 of 13 drugs abusers with acquired immunodeficiency syndrome-related complex (ARC). In one patient the virus was also found in cell-free plasma. No HTLV III/LAV was detected in or isolated from 5 clinically healthy drug abusers. The lymphocytes were cultured with interleukin 2 and expressed either a transcriptase reverse activity or HTLV III/LAV antigens within 2-3 weeks of cultivation. The viruses were also transmitted into normal lymphocytes from cord blood of human newborns. At the present state of development, virological investigation, other than seroepidemiological survey, seems a suitable marker for human retroviruses tracing in epidemiological studies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-01-01 | Microbiologica |