Antineoplastika, 14. Mitt.1) Cyclohexylderivate der 5-aminomethinylierten Barbitursäure

6533b81ffe1ef96bd12783a2

RESEARCH PRODUCT

Antineoplastika, 14. Mitt.1) Cyclohexylderivate der 5-aminomethinylierten Barbitursäure

subject

chemistry.chemical_compound Barbituric acid chemistry Stereochemistry Drug Discovery Pharmaceutical Science Medicinal chemistry

description

Aus der mit s-Triazin (1) durchfuhrbaren Aminomethinylierung der 1-Cyclohexyl- (2a) und 1,3-Dicyclohexylbarbitursaure (2b) gehen die korrespondierenden Cyclohexylderivate der 5-aminomethinylierten Barbitursaure 4a und 4b hervor. Insbesondere 4b vermag antineoplastische Effekte auszulosen. Antineoplastic Agents, XIV: Cyclohexyl Derivatives of 5-(Aminomethinyl)-barbituric Acid The aminomethinylation of 1-cyclohexyl- (2a) and 1,3-dicyclohexylbarbituric acid (2b) succeeds by means of s-triazine (1). It leads to the cyclohexyl derivatives 4a and 4b of 5-(aminomethinyl)barbituric acid. Particularly 4b is capable of exerting antineoplastic effects.

year	journal	country	edition	language
1983-01-01	Archiv der Pharmazie

https://doi.org/10.1002/ardp.19833160104

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