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RESEARCH PRODUCT
Modulation of aflatoxin B1 carcinogenicity, genotoxicity and metabolism in rat liver by dietary carotenoids: evidence for a protective effect of CYP1A inducers
M. SuschetetRaymond BergesPierre AstorgSandra GradeletAnne-marie Le Bonsubject
MaleVitaminCancer ResearchAflatoxinAflatoxin B1[SDV]Life Sciences [q-bio]MutagenBiologymedicine.disease_causeAntioxidants03 medical and health scienceschemistry.chemical_compound0404 agricultural biotechnologyAstaxanthinmedicineAnimalsAnticarcinogenic AgentsCanthaxanthinRats WistarVitamin ACarotenoidCarcinogenComputingMilieux_MISCELLANEOUS030304 developmental biologychemistry.chemical_classification0303 health sciencesINDUCTIONfood and beverages04 agricultural and veterinary sciencesCarotenoids040401 food scienceDietRats3. Good health[SDV] Life Sciences [q-bio]LiverOncologychemistryBiochemistryCarcinogensRATCARCINOGENESEGenotoxicityDNA DamageMethylcholanthrenedescription
The effects of several carotenoids of vitamin A and of 3-methylcholanthrene have been tested on the initiation of hepatocarcinogenesis by aflatoxin B1, using the sequential protocol of Solt and Farber. AFB1-induced DNA single-strand breaks and AFB1-metabolism were also assessed. The P4501A inducer carotenoids (canthaxanthin, astaxanthin, beta-apo-8'-carotenal) and 3-methylcholanthrene reduce the carcinogenicity of AFB1, divert AFB1-metabolism into the less genotoxic aflatoxin M1 and reduce AFB1-induced DNA single-strand breaks: we conclude that these carotenoids exert their protective effect through the deviation of AFB1 metabolism towards detoxification pathways. beta-Carotene decreased AFB1 carcinogenicity but did not alter its metabolism, probably acting by other mechanisms.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-01-01 |