6533b81ffe1ef96bd12786d2

RESEARCH PRODUCT

Activation of complement by the alternative pathway as a factor in the pathogenesis of periodontal disease.

D. Bitter-suermannH.u. SchorlemmerA.c. Allison

subject

T-LymphocytesGuinea PigsDental PlaqueAntigen-Antibody ComplexDental plaquePathogenesisstomatognathic systemPeriodontal diseasemedicineActinomycesAnimalsHumansActinomyces viscosusBone ResorptionPeriodontitisGlycoproteinsB-LymphocytesEnzyme Precursorsbusiness.industryMacrophagesGlobulinsGeneral MedicineComplement C3Complement System Proteinsmedicine.diseaseCathepsinsComplement (complexity)RatsEndotoxinsstomatognathic diseasesMicrobial CollagenaseImmunologyAlternative complement pathwaybusiness

description

Dental plaque and a bacterium, Actinomyces viscosus, isolated from plaque that can reproduce periodontal disease in germ-free rats, are activators of complement by the alternative pathway. It is suggested that this process is involved in the pathogenesis of chronic inflammatory periodontal disease.

yearjournalcountryeditionlanguage
1976-11-01Lancet (London, England)
10.1016/s0140-6736(76)90837-0https://pubmed.ncbi.nlm.nih.gov/62218