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RESEARCH PRODUCT

Schizophrenia polygenic risk score and long-term success in the labour market: A cohort study

Jutta ViinikainenPetri BöckermanChristian HakulinenJaana T. KariTerho LehtimäkiOlli T. RaitakariJaakko Pehkonen

subject

MaleEmploymentperinnölliset tauditskitsofrenia515 Psychologytyöllistyminen3121 Internal medicinebehavioral disciplines and activities3124 Neurology and psychiatryperinnöllinen alttiusEducationCohort Studiestyömarkkina-asemaPsychiatry and Mental healthkoulutustasoPolygenic risk scoreRisk FactorsEarningsSocial income transfersmental disordersSchizophreniaEducational StatusHumansBiological Psychiatry

description

Publisher Copyright: © 2022 The Authors Employment is rare among people with a schizophrenia diagnosis. Meanwhile, a genetic liability for schizophrenia may hinder labour market performance. We studied how the polygenic risk score (PGS) for schizophrenia related to education and labour market outcomes. We found that a higher PGS was linked to lower educational levels and weaker labour market outcomes as well as a higher likelihood of receiving social income transfers, particularly among men. Assuming that the link is causal, our results indicate that individuals with schizophrenia or schizophrenia-related traits have a weakened ability to fully participate in the labour market, potentially reinforcing social exclusion. Peer reviewed

yearjournalcountryeditionlanguage
2022-07-01Journal of Psychiatric Research
10.1016/j.jpsychires.2022.05.041http://dx.doi.org/10.1016/j.jpsychires.2022.05.041