6533b820fe1ef96bd12790ee
RESEARCH PRODUCT
Photothermal nanofibrillar membrane based on hyaluronic acid and graphene oxide to treat Staphylococcus aureus and Pseudomonas aeruginosa infected wounds.
Salvatore FedericoValentina CataniaFabio Salvatore PalumboCalogero FioricaDomenico SchillaciGiovanna PitarresiGaetano Giammonasubject
Staphylococcus aureusGeneral MedicineStaphylococcal InfectionsBiochemistryHyaluronan derivative Graphene oxide Nanofibers AntibiofilmAnti-Bacterial AgentsStructural BiologySettore CHIM/09 - Farmaceutico Tecnologico ApplicativoPseudomonas aeruginosaWound InfectionHumansGraphiteHyaluronic AcidMolecular Biologydescription
Here we reported the fabrication of an electrospun membrane based on a hyaluronic acid derivative (HA-EDA) to be used as a bandage for the potential treatment of chronic wounds. The membrane, loaded with graphene oxide (GO) and ciprofloxacin, showed photothermal properties and light-triggered drug release when irradiated with a near-infrared (NIR) laser beam. Free amino groups of HA-EDA derivative allowed autocrosslinking of the elec- trospun membrane; thus, a substantial enhancement in the hydrolytic resistance of the patch was obtained. In vitro antibacterial activity studies performed on Staphylococcus aureus and Pseudomonas aeruginosa revealed that such electrospun membranes, due to the synergistic effect of the antibiotic and NIR-mediated hyperthermia, reduced the viability of both pathogens. Specific in vitro experiment demonstrated also that is possible to disrupt, through laser irradiation, the biofilms formed onto the membrane.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-08-01 | International journal of biological macromolecules |