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RESEARCH PRODUCT
Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces.
Masaki J. HondaHiromichi ShinoShuichi SatoAkira HasuikeKeitaro IsokawaYoshinori Araisubject
Malemedicine.medical_specialtyBone RegenerationCalvariaOdontologíaOsseointegrationBone remodelingBone augmentationMelatonin03 medical and health sciences0302 clinical medicineInternal medicinemedicineAnimalsBone regenerationGeneral DentistryMelatoninbusiness.industryResearchSkull030206 dentistry:CIENCIAS MÉDICAS [UNESCO]Ciencias de la saludRats Inbred F344RatsSkullmedicine.anatomical_structureEndocrinologyOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASSurgeryOral Surgerybusiness030217 neurology & neurosurgeryhormones hormone substitutes and hormone antagonistsmedicine.drugdescription
Background Melatonin has many roles, including bone remodeling and osseointegration of dental implants. The topical application of melatonin facilitated bone regeneration in bone defects. We evaluated the effects of topical application of melatonin on vertical bone augmentation in rat calvaria secluded spaces. Material and Methods In total, 12 male Fischer rats were used and two plastic caps were fixed in the calvarium. One plastic cap was filled with melatonin powder and the other was left empty. Results Newly generated bone at bone defects and within the plastic caps was evaluated using micro-CT and histological sections. New bone regeneration within the plastic cap was increased significantly in the melatonin versus the control group. Conclusions Melatonin promoted vertical bone regeneration in rat calvaria in the secluded space within the plastic cap. Key words:Melatonin, bone regeneration, bone defects, secluded space, rat calvarium.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-06-24 | Medicina oral, patologia oral y cirugia bucal |