6533b820fe1ef96bd12792aa
RESEARCH PRODUCT
The emerging role of Notch pathway in ageing: Focus on the related mechanisms in age-related diseases
Carmela Rita BalistreriCalogero CarusoGerry MelinoRosalinda Madonnasubject
0301 basic medicineAgingNotchNotch pathwayNotch signaling pathwayInflammationa signaling complex networkBiologyBiochemistryBiomarkers and targets for personalized treatmentBiomarkers and targets for personalized treatments03 medical and health sciencesAge relatedAge-related diseaseReceptorsmedicineA signaling complex network; Age-related diseases; Ageing; Biomarkers and targets for personalized treatments; Involved mechanisms; Notch pathway; Aging; Animals; Homeostasis; Humans; Inflammation; Inflammation Mediators; Receptors Notch; Signal TransductionAnimalsHomeostasisHumansMolecular BiologyInflammationInnate immune systemReceptors NotchSettore BIO/11Involved mechanismsAge-related diseases; Ageing; Biomarkers and targets for personalized treatments; Involved mechanisms; Notch pathway; a signaling complex networkPhenotypeInvolved mechanismAgeing030104 developmental biologyNeurologyAgeingImmunologymedicine.symptomSignal transductionInflammation MediatorsNeuroscienceHomeostasisAge-related diseasesBiotechnologySignal Transductiondescription
Notch signaling is an evolutionarily conserved pathway, which is fundamental for the development of all tissues, organs and systems of human body. Recently, a considerable and still growing number of studies have highlighted the contribution of Notch signaling in various pathological processes of the adult life, such as age-related diseases. In particular, the Notch pathway has emerged as major player in the maintenance of tissue specific homeostasis, through the control of proliferation, migration, phenotypes and functions of tissue cells, as well as in the cross-talk between inflammatory cells and the innate immune system, and in onset of inflammatory age-related diseases. However, until now there is a confounding evidence about the related mechanisms. Here, we discuss mechanisms through which Notch signaling acts in a very complex network of pathways, where it seems to have the crucial role of hub. Thus, we stress the possibility to use Notch pathway, the related molecules and pathways constituting this network, both as innovative (predictive, diagnostic and prognostic) biomarkers and targets for personalised treatments for age-related diseases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-01-01 |