6533b820fe1ef96bd12799cb
RESEARCH PRODUCT
Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk
Pedro J. SanzEva M Asensio-marquezDolores CorellaLaura Zanon-morenoMaria D Pinazo-duranJose M. OrdovasJose M. OrdovasJose M. OrdovasVicente Zanon-morenoCarolina Ortega-azorínJose Javier Garcia-medinasubject
Geneticsmedicine.medical_specialtyeducation.field_of_studyOpen angle glaucomabusiness.industryPopulationGlaucomamedicine.diseaseGastroenterologyeye diseasesExfoliative glaucomaOddsOphthalmologyInternal medicineGenetic modelTaqManMedicineAllelebusinesseducationdescription
Background To investigate the possible association of the rs2165241 polymorphism (C > T) in LOXL1 gene with the risk of primary open-angle glaucoma in a Mediterranean population. Methods The analysis of genetic polymorphisms was performed by standard TaqMan allelic discrimination technique, using a 7900HT Sequence Detection System (Applied Biosystems). Results In a recessive genetic model, the T allele of the rs2165241 polymorphism was significantly associated with the risk of primary open-angle glaucoma (TT vs. CC: odds ratios = 2.19, 95% confidence interval = [1.33–3.62]). After multivariate logistic regression model adjusted by age and weight, the magnitude of the association decreased but remained statistically significant (TT vs. CC: odds ratios = 2.07, 95% confidence interval = [1.20–3.57]). Conclusion This polymorphism seems to be associated with high risk for primary open-angle glaucoma in a Mediterranean population.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-08-07 | Clinical & Experimental Ophthalmology |