6533b820fe1ef96bd1279cbe

RESEARCH PRODUCT

Patients with Inflammatory Bowel Disease Are Not at Increased Risk of COVID-19: A Large Multinational Cohort Study

Adi LahatCarolina PalmelaSilvio DaneseGionata FiorinoVassilios NtelisMaría ChaparroGiorgos BamiasLaurent Peyrin-birouletHaidee A. GonzalezIoannis PapaconstantinouPierre EllulUri KopylovShomron Ben HorinKonstantinos H. KatsanosShaji SebastianYulia UspenskayaMarta Maia Bosca-wattsJoanna TorresFerdinando D'amicoFerdinando D'amicoGerassimos J. MantzarisMariangela AlloccaEirini ZacharopoulouDimitrios K. ChristodoulouJavier P. Gisbert

subject

medicine.medical_specialtyPopulationlcsh:MedicineInflammatory bowel diseaseArticledrugslaw.invention03 medical and health sciences0302 clinical medicinelawinflammatory bowel diseaseInternal medicinemedicineCumulative incidenceeducationeducation.field_of_studyimmunosuppressionbusiness.industryIncidence (epidemiology)lcsh:RCOVID-19General Medicinemedicine.diseaseIntensive care unitdigestive system diseasesPneumonia030220 oncology & carcinogenesisCohort030211 gastroenterology & hepatologybusinessCohort study

description

The impact of COVID-19 on inflammatory bowel disease (IBD) patients under pharmacological immunosuppression is still not clearly understood. We investigated the incidence of COVID-19 and the impact of immunosuppression and containment measures on the risk of SARS-CoV-2 infection in a large IBD cohort, from a multicenter cohort from 21st of February to 30th of June, 2020. Ninety-seven patients with IBD (43 UC, 53 CD, one unclassified IBD) and concomitant COVID-19 over a total of 23,879 patients with IBD were enrolled in the study. The cumulative incidence of SARS-CoV-2 infection in patients with IBD vs. the general population was 0.406% and 0.402% cases, respectively. Twenty-three patients (24%) were hospitalized, 21 (22%) had pneumonia, four (4%) were admitted to the Intensive Care Unit, and one patient died. Lethality in our cohort was 1% compared to 9% in the general population. At multivariable analysis, age &gt

yearjournalcountryeditionlanguage
2020-10-31Journal of Clinical Medicine
10.3390/jcm9113533https://www.mdpi.com/2077-0383/9/11/3533