6533b820fe1ef96bd127a387

RESEARCH PRODUCT

Die Hemmung der Aufnahme vonα-Methylnoradrenalin in das Herz durch sympathomimetische Amine

Erich MuschollE. Weber

subject

PharmacologyPerfusion fluidChromatographyStereochemistryChemistryPharmacology toxicologyTyrode solutionAmine gas treatingGeneral Medicine

description

Hearts of rabbits were isolated and perfused with Tyrode solution containing 10 ng/ml (−)-α-methyl noradrenaline. The uptake by the heart ofα-methyl-noradrenaline was calculated by estimating the amount of amine removed from the perfusion fluid while passing through the heart. In control experiments the mean removal ofα-methyl noradrenaline was 43,7 ± 1,6% of the amount infused. The rate of removal remained constant throughout the time period of the experiment, i.e. 20 min.

https://doi.org/10.1007/bf02308519