6533b820fe1ef96bd127a388
RESEARCH PRODUCT
Endometrial Adenocarcinoma in Syrian Hamsters Treated with Diethylstilbestrol, Tamoxifen and N-Ethyl-Nitrosourea
Antonio LealFaustino Pérez-mínguezAntonio Llombart-boschJaime FerrerAmando Peydrósubject
business.industryDiethylstilbestrolEstrogen receptorHamsterAntiestrogenHyperestrogenismmedicine.diseaseEndometriumEndometrial hyperplasiamedicine.anatomical_structuremedicineCancer researchmedicine.symptomskin and connective tissue diseasesbusinesshormones hormone substitutes and hormone antagonistsTamoxifenmedicine.drugdescription
The synthetic estrogen diethylstilbestrol (DES) causes marked abnormalities in the female hamster genital tract, after either prenatal or postnatal exposure, leading to endometrial hyperplasia and carcinoma. Acting as an initiating event, DES altering uterine development may facilitate the abnormal response of promoting agents. Tamoxifen (TAM) is an antiestrogen that competes for central and peripheral estrogen receptor (ERα). TAM exerts agonistic effects on E-dependent endometrial proliferation. N-ethyl-N-nitrosourea (ENU), a potent mutagenic agent, induces tumors in a variety of organs, predominantly in the peripheral nervous system. To test whether ENU and TAM treatment in a model of hyperestrogenism, the histopathologic endometrial alterations following exposure to DES, ENU and TAM (alone or in combination) were analyzed in ovariectomized female Syrian hamsters. Herein, the incidence and characteristics of the lesions found in the endometrium, and the progressive transformation from early alterations to malignant processes, are presented and discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-08-09 |