6533b820fe1ef96bd127a526
RESEARCH PRODUCT
Clear Cell Syringoid Carcinoma
Carmen CardaJaime FerrerCarlos MonteagudoDavid RamosEncarna MontesinosAmando Peydro-olayasubject
Pathologymedicine.medical_specialtyPopulationPerineural invasionDermatologyBiologyMalignancyPathology and Forensic MedicineCarcinoembryonic antigenCarcinomamedicineHumanseducationAgedAged 80 and overeducation.field_of_studyScalpCarcinomaS100 ProteinsGeneral Medicinemedicine.diseaseCarcinoembryonic AntigenSweat Gland NeoplasmsClear cell carcinomabiology.proteinKeratinsImmunohistochemistryFemaleClear celldescription
Syringoid carcinoma (syringoid "eccrine" carcinoma or eccrine epithelioma) is a rare cutaneous tumor with some controversy regarding its correct definition. It may also be difficult to differentiate from its benign counterpart (syringoma), other adnexal carcinomas, and cutaneous metastasis from adenocarcinomas. We present a case of a syringoid carcinoma of the clear cell variant complemented with an immunohistochemical and ultrastructural study, the latter revealing cytoplasmic accumulation of glycogen and presence of intercellular and intracellular lumina in clear tumor cells, as well as diverse hallmarks of malignancy (i.e., perineural invasion, tumor necrosis, and deep invasion). Clear tumor cells showed cytoplasmic and membranous immunoreactivity to epithelial membrane antigen, carcinoembryonic antigen, keratins, and S-100. Our ultrastructural and immunohistochemical results support the ductal differentiation of the glycogen-filled clear cell tumor population.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2000-03-04 | The American Journal of Dermatopathology |