6533b820fe1ef96bd127a57a
RESEARCH PRODUCT
International consensus guidelines for scoring the histopathological growth patterns of liver metastasis
Fernando Vidal-vanaclochaEric P. Van Der StokAli W. MajeedMichael SchvimerSteven Van LaereRobert R. J. Coebergh Van Den BraakAndrew R. ReynoldsAndrew R. ReynoldsPnina BrodtEve SimoneauGert Van Den EyndenRoni F. RayesNigel C. BirdMaria Celia FernandezOle Didrik LaerumLaure Anne TeuwenPeter B. VermeulenMartin IllemannAnthoula LazarisCornelis VerhoefMark M. KockxPeter MetrakosPeter A. Van DamYves SucaetMichelle Van De PaerHanna NyströmLuc DirixSophia FrentzasDirk J. GrünhagenZu-hua GaoHardeep Singh MudharRikke Løvendahl EefsenBoris Galjartsubject
0301 basic medicineOncologycongenital hereditary and neonatal diseases and abnormalitiesCancer Researchmedicine.medical_specialtyPathologyIntraclass correlationmedicine.medical_treatmentcolorectal cancerGuidelineMetastasisangiogenesis03 medical and health sciencesbreast cancer0302 clinical medicineSDG 3 - Good Health and Well-beingInternal medicineJournal ArticlemedicineHumansNeoplasm Metastasisprognostic factorintegumentary systembusiness.industryLiver Neoplasmsnutritional and metabolic diseasesvessel co-optionGold standard (test)medicine.diseaseliver metastasis030104 developmental biologyTissue sectionsPractice GuidelineOncology030220 oncology & carcinogenesisCancer cellCohortBiomarker (medicine)Hepatectomytumour microenvironmentbusinessdescription
BACKGROUND: Liver metastases present with distinct histopathological growth patterns (HGPs), including the desmoplastic, pushing and replacement HGPs and two rarer HGPs. The HGPs are defined owing to the distinct interface between the cancer cells and the adjacent normal liver parenchyma that is present in each pattern and can be scored from standard haematoxylin-and-eosin-stained (H&E) tissue sections. The current study provides consensus guidelines for scoring these HGPs.METHODS: Guidelines for defining the HGPs were established by a large international team. To assess the validity of these guidelines, 12 independent observers scored a set of 159 liver metastases and interobserver variability was measured. In an independent cohort of 374 patients with colorectal liver metastases (CRCLM), the impact of HGPs on overall survival after hepatectomy was determined.RESULTS: Good-to-excellent correlations (intraclass correlation coefficient >0.5) with the gold standard were obtained for the assessment of the replacement HGP and desmoplastic HGP. Overall survival was significantly superior in the desmoplastic HGP subgroup compared with the replacement or pushing HGP subgroup (P=0.006).CONCLUSIONS: The current guidelines allow for reproducible determination of liver metastasis HGPs. As HGPs impact overall survival after surgery for CRCLM, they may serve as a novel biomarker for individualised therapies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-07 | British Journal of Cancer |