6533b821fe1ef96bd127ad5a

RESEARCH PRODUCT

Biomonitoring of parabens in human milk and estimated daily intake for breastfed infants

Olga PardoVicent YusàMáximo VentoFrancisca Corpas-burgosPablo DualdeMaría GormazJulia KuligowskiAgustín Pastor

subject

Environmental EngineeringDaily intakeHealth Toxicology and Mutagenesis0208 environmental biotechnologyEstimated daily intakeParabensMothers02 engineering and technology010501 environmental sciences01 natural sciencesAnimal scienceFrequency detectionBiomonitoringEnvironmental ChemistryMedicineHumans0105 earth and related environmental sciencesMilk Humanbusiness.industryHuman milkPublic Health Environmental and Occupational HealthInfant Newbornfood and beveragesInfantGeneral MedicineGeneral ChemistryPollution020801 environmental engineeringHuman biomonitoringBreast FeedingFemalebusinessEstimated daily intake Human biomonitoring Human milk Infants Mothers ParabensInfantsBiological Monitoring

description

In this study, we assessed the presence of four parabens in human milk of 120 mothers from Valencia (Spain) which took part in a human biomonitoring project (BETTERMILK). The detection frequency ranges of parabens were 41-60% and 61-89% for unconjugated- and total (unconjugated + conjugated)-parabens, respectively. The concentrations ranged from <LoQ to 31 ng/mL and from <LoQ to 49 ng/mL for unconjugated- and total-parabens, respectively. The frequency of use of some cosmetic products and human milk protein levels were the main predictors of parabens in milk. The study evidences the presence of both conjugated and unconjugated paraben forms in human milk. The newborns estimated daily intake of parabens through human milk was several orders of magnitude lower than the 0-10 mg/kg bw-day acceptable daily intake for the sum of methyl and ethyl paraben established by EFSA. To our knowledge, this is currently the largest biomonitoring study of parabens in human milk. (C) 2019 Elsevier Ltd. All rights reserved.

yearjournalcountryeditionlanguage
2020-01-01
https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=4297