Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

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RESEARCH PRODUCT

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

Mario G. Mirisola Mario G. Mirisola Jaime Guevara-aguirre Min Wei Priya Balasubramanian Morgan E. Levine Chia-wei Cheng Giuseppe Passarino Junxiang Wan Eileen M. Crimmins Pinchas Cohen Luigi Fontana Luigi Fontana Sebastian Brandhorst Valter D. Longo Brian K. Kennedy Jorge Suarez Federica Madia

subject

Male medicine.medical_specialty Low protein nutrition protein intake caloric restriction nutrients Physiology medicine.medical_treatment Longevity Calorie restriction Breast Neoplasms Growth hormone receptor Biology Article Mice Low-protein diet Neoplasms Diabetes mellitus Internal medicine Diabetes Mellitus Diet Protein-Restricted medicine Animals Humans Insulin-Like Growth Factor I Melanoma Molecular Biology Aged Proportional Hazards Models Mice Knockout Mice Inbred BALB C Incidence (epidemiology)Cancer Cell Biology Middle Aged medicine.disease Middle age Mice Inbred C57BL Cross-Sectional Studies Endocrinology Female Carrier Proteins Follow-Up Studies Signal Transduction

description

SummaryMice and humans with growth hormone receptor/IGF-1 deficiencies display major reductions in age-related diseases. Because protein restriction reduces GHR-IGF-1 activity, we examined links between protein intake and mortality. Respondents aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer death risk during the following 18 years. These associations were either abolished or attenuated if the proteins were plant derived. Conversely, high protein intake was associated with reduced cancer and overall mortality in respondents over 65, but a 5-fold increase in diabetes mortality across all ages. Mouse studies confirmed the effect of high protein intake and GHR-IGF-1 signaling on the incidence and progression of breast and melanoma tumors, but also the detrimental effects of a low protein diet in the very old. These results suggest that low protein intake during middle age followed by moderate to high protein consumption in old adults may optimize healthspan and longevity.

year	journal	country	edition	language
2014-03-01	Cell Metabolism

https://doi.org/10.1016/j.cmet.2014.02.006