6533b821fe1ef96bd127aea2
RESEARCH PRODUCT
Comparative investigations on the actions of ACTH1-24, somatostatin, neurotensin, substance P and vasopressin on locus coeruleus neuronal activity in vitro.
Helmut L. HaasMartin W. SteinmannHans Rudolf OlpeMario F. Pozzasubject
Maleendocrine systemmedicine.medical_specialtyVasopressinVasopressinsNeuropeptideSubstance PIn Vitro TechniquesSubstance Pchemistry.chemical_compoundSlice preparationInternal medicinemedicinePremovement neuronal activityAnimalsNeurotensinPharmacologyNeuronsChemistryNeuropeptidesGeneral MedicineArginine VasopressinEndocrinologySomatostatinnervous systemLocus coeruleusCosyntropinLocus CoeruleusGerbillinaeSomatostatinhormones hormone substitutes and hormone antagonistsNeurotensindescription
A considerable number of neuropeptides have been localized immunohistochemically in the area of the locus coeruleus of the rat. The objective of this study was to assess the actions of some of these transmitter candidates on spontaneously active locus coeruleus neurons in vitro. The effects of bath-applied peptides on the discharge rate of individual locus coeruleus neurons were investigated. A midpontine slice preparation of the gerbil brain was used. Excitatory dose-dependent effects were found with four peptides with the following rank order of potency: Substance P, (Arg8)-vasopressin, neurotensin, ACTH1–24. Somatostatin hyperpolarized all neurons tested. Given the pronounced effects seen with substance P, somatostatin and vasopressin in the nanomolar range, it is conceivable that these peptides may have a role in regulating neuronal activity in locus coeruleus.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1987-10-01 | Naunyn-Schmiedeberg's archives of pharmacology |