6533b821fe1ef96bd127af0e

RESEARCH PRODUCT

S-100 protein positive cells in nasopharyngeal carcinoma (NPC): absence of prognostic significance. A clinicopathological and immunohistochemical study of 40 cases

C MicheauFrancisco Vera-sempereA. Llombart-bosch

subject

AdultMalePathologymedicine.medical_specialtyAdolescentNasopharyngeal neoplasmTumor cellsPositive correlationPathology and Forensic MedicinemedicineHumansStatistical analysisChildCàncerMolecular Biologybusiness.industryS100 ProteinsNas MalaltiesNasopharyngeal NeoplasmsCell BiologyGeneral MedicineMiddle Agedmedicine.diseasePrognosisNeoplasm ProteinsNasopharyngeal carcinomaImmunologic TechniquesImmunohistochemistryFemalebusiness

description

An immunohistochemical study of S-100 protein in 43 nasopharyngeal carcinomas (NPC) of known clinical evolution (33 primary and 10 metastatic) is presented. Sixty per cent of primary site cases as well as all metastatic forms showed S-100 protein positive cells intermingled with tumour cells. These S-100 positive elements were identified as Langerhans cells. No significant differences were found when correlating S-100 protein positivity and histological NPC variants, neither in age nor in sex of patients. Statistical analysis failed to demonstrate any positive correlation between S-100 protein reactivity and clinical survival.

yearjournalcountryeditionlanguage
1987-01-01
10.1007/bf00735028https://doi.org/10.1007/BF00735028