6533b821fe1ef96bd127b6fc
RESEARCH PRODUCT
A new polyphosphate calcium material with morphogenetic activity
Heinz-christoph SchröderEmad TolbaThorben LinkX WangRafael Muñoz-espíWerner E.g. MüllerShunfeng WangGunnar Glassersubject
Reaction conditionsMaterials scienceMechanical EngineeringPolyphosphatechemistry.chemical_elementpathological conditions signs and symptomsCalciumIn vitro incubationCondensed Matter PhysicsRegenerative medicinedigestive system diseaseschemistry.chemical_compoundsurgical procedures operativechemistryBiochemistryTissue engineeringMechanics of MaterialsBone cellotorhinolaryngologic diseasesGeneral Materials ScienceneoplasmsSaos-2 cellsdescription
Abstract Polyphosphate [polyP] has been proven to elicit morphogenetic activity on bone cells. By applying mild reaction conditions, a Ca-polyP material that displays a hardness of ≈1.3 GPa has been fabricated. The Ca-polyP granules are prone to hydrolytic degradation during in vitro incubation of the cells, suggesting that this property is associated with the observed bioactivity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-06-01 | Materials Letters |