6533b821fe1ef96bd127b82a

RESEARCH PRODUCT

Blood Anticoagulant Activity of Sulphated Ovular Mucins of Amphibians

A. MingantiG. Bellia

subject

Multidisciplinarybiologymedicine.diagnostic_testSulfatesurogenital systemChemistryProteolysisMucinMucinsAnticoagulantsFibrinogenbiology.organism_classificationAnticoagulant activityAmphibiansPapainchemistry.chemical_compoundBiochemistrymedicineAnimalsHumanssense organsBufohormones hormone substitutes and hormone antagonistsmedicine.drugWhole blood

description

THE mucin constituting the gelatinous layer which envelops the eggs of Bufo bufo, if digested with papain and then sulphated, shows a marked anticoagulant activity on the fibrinogen and the whole blood plasma1. A similar anticoagulant activity has now been shown by the ovular mucins of other species of amphibians, sulphated without any previous proteolysis.

https://doi.org/10.1038/1791351a0