6533b821fe1ef96bd127b84b
RESEARCH PRODUCT
Ten kilodalton heat shock protein (HSP10) is overexpressed during carcinogenesis of large bowel and uterine exocervix
Marianna BellafioreGiovanni ZummoSabrina DavidRita AnzaloneFrancesco Cappellosubject
AdenomaPathologymedicine.medical_specialtyDysplasiaCancer ResearchUterine Cervical NeoplasmsBiologymedicine.disease_causeIn vivoHeat shock proteinCarcinogenesis; Carcinoma; Dysplasia; Heat shock proteins; Cancer Research; Molecular Biology; OncologymedicineCarcinomaChaperonin 10HumansMolecular BiologyCarcinogenesiHeat shock proteinHistocytochemistryCarcinomamedicine.diseaseUterine Cervical DysplasiaBlotOncologyDysplasiaColonic NeoplasmsCancer researchImmunohistochemistryHSP60FemaleCarcinogenesisdescription
In the present study, we evaluated the presence and the level of expression of HSP10 in two carcinogenetic models: the 'adenoma-carcinoma sequence' of large bowel and the 'dysplasia-carcinoma sequence' of uterine exocervix. We found HSP10 was overexpressed during the carcinogenesis of both organs. In particular, HSP10 was overexpressed early in large bowel carcinogenesis, while the expression of this protein in exocervical carcinogenesis gradually increased from normal through dysplastic to neoplastic tissues. The quantitative analysis of immunohistochemistry and the Western blotting confirmed these results. Our previous observations showed overexpression of HSP60 in the same carcinogenetic models. This report correlates the overexpression of HSP10 with that of HSP60 during carcinogenesis in vivo. These results could stimulate further studies on the pathogenetic role of these proteins during the carcinogenesis as well as their use as diagnostic and prognostic tools in oncology. © 2003 Elsevier Science Ltd. All rights reserved.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-01-01 |