Prognostische Bedeutung des e-Cadherin beim papillären Schilddrüsencarcinom

6533b821fe1ef96bd127c0dd

RESEARCH PRODUCT

Prognostische Bedeutung des e-Cadherin beim papillären Schilddrüsencarcinom

Fernando Bittinger E Sternheim Siegfried Walgenbach J. Andreas Theodor Junginger R. Gorges

subject

medicine.medical_specialty business.industry medicine.medical_treatment Thyroidectomy Retrospective cohort study medicine.disease Gastroenterology Thyroid carcinoma Cardiothoracic surgery Internal medicine medicine Carcinoma Immunohistochemistry Surgery business Survival rate Abdominal surgery

description

The prognostic significance of e-cadherin in papillary thyroid carcinoma was evaluated in a retrospective study. From September 1985 to December 1996, 113 patients underwent surgery for papillary thyroid carcinoma. Seventy-eight formalin-fixed, paraffin-embedded tissue samples were available for immunohistochemical analysis of e-cadherin expression. In 74 of these 78 patients the postoperative course is known for 2 months to 35.2 years (median 3.6 years, mean: 4.9 +/- 4.8 years). Reduced or negative e-cadherin expression ( 20%. Statistical analysis revealed e-cadherin expression ( 20%), synchronous distant metastasis (M0/pM1, cM1) and radicality of resection (R0/R1, 2) as significant risk factors for survival. Our findings provide evidence that e-cadherin is a prognostic factor in papillary thyroid carcinoma.

year	journal	country	edition	language
1998-02-01	Der Chirurg

https://doi.org/10.1007/s001040050394

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