6533b821fe1ef96bd127c11f

RESEARCH PRODUCT

Selektive Blutentnahme aus dem Sinus petrosus inferior: Vergleich von CRF- und TRH-Stimulation

Holger StrunkTh. StrackGeorge J. KahalyJ. BeyerJuergen SchrezenmeirHans H. SchildPeter Mildenberger

subject

Pituitary glandmedicine.medical_specialtyAdenomabusiness.industryInferior petrosal sinusStimulationRadioimmunoassaymedicine.diseaseProlactinCushing syndromemedicine.anatomical_structureEndocrinologyInternal medicinemedicineRadiology Nuclear Medicine and imagingbusinessBlood sampling

description

In 10 patients with hypophyseal Cushing microadenomas, selective bilateral sampling from the inferior petrosal sinuses was performed and the effect of stimulation by iv TRH and CRF was compared. On the side of the microadenoma. ACTH concentration rose from 650 +/- 242 pg/ml to 2712 +/- 843 pg/ml following injection of CRF and 2025 +/- 242 pg/ml after TRH. Contralateral values were 165 +/- 79 pg/ml, 490 +/- 200 pg/ml and 165 +/- 72 pg/ml respectively. Prolactin concentration on the side of the adenoma was 98 +/- 49 ng/ml before stimulation, 236 +/- 62 ng/ml after CRF and 747 +/- 168 ng/ml after TRH. Contralateral concentration was 22 +/- 10 ng/ml, 64 +/- 19 ng/ml respectively. Sampling localised all adenomas correctly, whereas contrast-enhanced MRT diagnosed only four adenomas.

yearjournalcountryeditionlanguage
1993-01-01RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren
https://doi.org/10.1055/s-2008-1032598