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RESEARCH PRODUCT

Obesity and Circulating Levels of Vitamin D before and after Weight Loss Induced by a Very Low-Calorie Ketogenic Diet

Cristiana RandazzoAntonio M. BorzìSabina GurreraFrancesco MeliGiuseppe RosafioRosalia CaldarellaSilvio BuscemiCarola BuscemiSalvatore MilazzoDavide CorleoGiovanni De PergolaMarcello CiaccioAnna Maria BarileValentina Settipani

subject

AdultMalemedicine.medical_specialtyobesitymedicine.medical_treatmentvitamin D.chemistry.chemical_elementAdipose tissuevitamin DCalciumArticlePhosphorus metabolismCohort StudiesparathormoneWeight lossInternal medicineWeight LossVitamin D and neurologyHumansMedicineTX341-641Settore MED/49 - Scienze Tecniche Dietetiche ApplicateNutrition and DieteticsNutrition. Foods and food supplybusiness.industryfat massMiddle Agedmedicine.diseaseObesityEndocrinologyAdipose TissuechemistryParathyroid Hormoneketogenic dietfat maFemalemedicine.symptomDiet KetogenicbusinessBody mass indexFood ScienceKetogenic diet

description

Background: Vitamin D plays a pivotal role in calcium and phosphorus metabolism, also influencing bone tissue. Several studies have reported that vitamin D blood levels were significantly lower in people with obesity, probably due to its uptake by the adipose tissue. Clinical studies that investigated the changes of circulating levels of vitamin D following weight loss reported controversial data. A very low-calorie ketogenic diet is acknowledged as a reliable treatment to achieve a rapid weight loss. Therefore, we investigated the effect of weight loss, consequent to a very low-calorie ketogenic diet, on vitamin D blood concentrations. Methods: A cohort of 31 people with obesity underwent a very low-calorie ketogenic diet for 10–12 weeks. The serum concentrations of vitamin D, parathormone, calcium and phosphorous were measured before and after weight loss

yearjournalcountryeditionlanguage
2021-05-27Nutrients
10.3390/nu13061829http://dx.doi.org/10.3390/nu13061829