6533b821fe1ef96bd127c451
RESEARCH PRODUCT
Structural considerations on the iridoids as anti-inflammatory agents.
José-luis RíosS. MáñezRosa M. GinerMaría Del Carmen Reciosubject
Iridoid GlycosidesIridoidmedicine.drug_classAnti-Inflammatory AgentsPharmaceutical ScienceIridoid GlucosidesAnalytical Chemistrychemistry.chemical_compoundMiceStructure-Activity RelationshipEdemaDrug DiscoverymedicineAnimalsGlycosidesAucubinPharmacologyChemistryLoganinTerpenesOrganic ChemistryCatalpolVerbenalinComplementary and alternative medicineBiochemistryMolecular MedicineFemalemedicine.symptomdescription
Abstract Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4% edema inhibition) on the former test, whereas the catalpol derivative mixture isolated from Scrophularia, aucubin, verbenalin, and loganin, showed the highest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-06-01 | Planta medica |