6533b822fe1ef96bd127ce58
RESEARCH PRODUCT
Clean method for the simultaneous determination of propyphenazone and caffeine in pharmaceuticals by flow injection Fourier transform infrared spectrometry.
Zouhair BouhsainSalvador GarriguesMiguel De La Guardiasubject
ChemistryChemistry PharmaceuticalAnti-Inflammatory Agents Non-SteroidalAnalytical chemistryInfrared spectroscopyBiochemistryAnalytical Chemistrylaw.inventionSolventAbsorbancelawCaffeineSpectroscopy Fourier Transform InfraredElectrochemistrymedicineSolventsEnvironmental ChemistryFourier transform infrared spectroscopyDissolutionPropyphenazoneDistillationSpectroscopyFiltrationAntipyrinemedicine.drugdescription
A procedure is proposed for the simultaneous FTIR determination of propyphenazone (PFZ) and caffeine (CAF) in pharmaceuticals. The method involves the dissolution of the active principles in CHCl 3 , followed by filtration of sample solutions to remove the excipients. PFZ is then determined by absorbance measurements at 1595 cm - 1 , using a baseline established between 2000 and 890 cm - 1 , and CAF by using the first-derivative values at 1712 cm - 1 , using solutions of PFZ and CAF for external calibration. The method was applied in both the stopped-flow and flow-injection modes, providing precise and accurate results for the analysis of real samples. The incorporation of a distillation unit for the on-line recycling of the CHCl 3 used as carrier and solvent provides an environmentally friendly analytical methodology which makes possible an injection frequency of 120 samples h - 1 and reduces the cost and side-effects of the production of laboratory waste.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-05-01 | The Analyst |