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RESEARCH PRODUCT
Functional Magnetic Mesoporous Silica Microparticles Capped with an Azo-Derivative: A Promising Colon Drug Delivery Device
Daniel FerriDaniel FerriAna M. CosteroAna M. CosteroM. Dolores MarcosRamón Martínez-máñezPablo GaviñaPablo GaviñaCarmen CollVirginia MerinoVirginia MerinoAdrián H. TeruelMarta González-álvarezFélix SancenónMargarita ParraMargarita Parrasubject
Pharmaceutical Science02 engineering and technologyFerric Compounds01 natural sciencesazo reductorcolon releaseAnalytical ChemistrySodium dithionitechemistry.chemical_compoundQUIMICA ORGANICADrug DiscoveryMoietymagnetic mesoporous silicaDrug CarriersAqueous solutionHydrolysisHydrogen-Ion ConcentrationSilicon Dioxide021001 nanoscience & nanotechnologyControlled releaseMicrospheresChemistry (miscellaneous)Drug deliveryMolecular Medicine0210 nano-technologyOxidation-ReductionPorosityColonSurface Properties010402 general chemistryArticleMagneticsChloridesSafraninQUIMICA ANALITICAHumansFerrous CompoundsPhysical and Theoretical Chemistrymagnetic mesoporous silica; azo derivatives; pH triggered; azo reductor; colon releaseQUIMICA INORGANICAOrganic ChemistryDithioniteMesoporous silica0104 chemical sciencesDrug LiberationchemistryNanoparticlesPhenazinespH triggeredMesoporous materialAzo Compoundsazo derivativesNuclear chemistrydescription
[EN] Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1. Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold. However, in the presence of sodium dithionite (azoreductive agent), a remarkable safranin O delivery was observed. At acidic pH, a certain safranin O release from S1 was also found. The pH-triggered safranin O delivery was ascribed to the acid-induced hydrolysis of the carbamate moiety that linked the bulky azo derivatives onto the mesoporous inorganic magnetic support. The controlled release behavior of S1 was also tested using a model that simulated the gastro intestinal tract.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-10 | Molecules; Volume 23; Issue 2; Pages: 375 |