6533b822fe1ef96bd127d76c
RESEARCH PRODUCT
Angiogenesis in oral lichen planus: an in vivo and immunohistological evaluation.
Emiliano MaresiPietro MessinaGiuseppe Alessandro ScardinaAlessia Ruggierisubject
MaleVascular Endothelial Growth Factor APathologymedicine.medical_specialtyAngiogenesisImmunologyBiologyMicroscopic AngioscopyPathogenesisNeovascularizationchemistry.chemical_compoundstomatognathic systemIn vivoSettore MED/28 - Malattie OdontostomatologichemedicineImmunology and AllergyHumansOral mucosaangiogenesis Videocapillaroscopy VEGF ImmunohistochemistryAutoimmune diseaseNeovascularization PathologicGeneral MedicineMiddle Agedmedicine.diseaseImmunohistochemistryCapillariesVascular endothelial growth factorstomatognathic diseasesmedicine.anatomical_structurechemistryCase-Control StudiesOral lichen planusFemalemedicine.symptomCell Adhesion MoleculesLichen Planus Oraldescription
Oral lichen planus (OLP) is an autoimmune disease with an inflammatory pathogenesis. The angiogenetic phenomenon is a mechanism at the base of the pathogenesis of chronic inflammatory processes. The aim of this research is to evaluate the angiogenetic phenomenon, comparing an in vitro method with an in vivo one. Thirty OLP patients and 30 healthy subjects were enrolled in the study. Immunohistochemical analysis of the vascular-endothelial growth factor (VEGF) and vascular-endothelial adhesion molecules were carried out by the means of primary antibodies and anti-CD34, anti-VEGF, anti-CD106 antigen (VCAM-1) and anti-CD54 antigen (ICAM-1). Capillary density and others capillaroscopic parameters were tested in vivo using oral videocapillaroscopy. The results reveal the presence of a significant angiogenesis in OLP patients through the immunoexpression of VEGF, CD34, CD106 and CD54 (p < 0.001). Capillaroscopic analysis demonstrates significant value for the following parameters: density, tortuosity, loop diameter, afferent and efferent capillary loop diameter. The in vivo and in vitro investigation in OLP reveals a significant angiogenesis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-07-06 | Archivum immunologiae et therapiae experimentalis |