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RESEARCH PRODUCT

Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model

Del Castillo JlGarcía-arranz MRuiz-bravo EJ. Hernández-godoyEstefanía Alonso-rodríguezGonzález-martín-moro JPozo-kreilinger JjJosé-luis Cebrián-carreteroMiguel Burgueño

subject

Pathologymedicine.medical_specialtymedicine.medical_treatmentReviewBone remodelingMice03 medical and health sciences0302 clinical medicinemedicineAnimalsRats WistarGeneral DentistryDental alveolusBisphosphonate-associated osteonecrosis of the jawBone Density Conservation AgentsDiphosphonatesbusiness.industryStem CellsImidazolesOsteonecrosis030206 dentistryBisphosphonate:CIENCIAS MÉDICAS [UNESCO]medicine.diseaseRatsDisease Models AnimalBone Density Conservation AgentsZoledronic acidOtorhinolaryngologyUNESCO::CIENCIAS MÉDICASTooth ExtractionBisphosphonate-Associated Osteonecrosis of the JawSurgeryOral SurgeryStem cellbusinessOsteonecrosis of the jawmedicine.drug

description

Background Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. Material and Methods 38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed. Results The presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls. Conclusions In this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCs. Key words:Osteonecrosis; bisphosphonates, Mesenchymal stem cells (MSC), adipose-derived stem cells (ASCs), zoledronic acid.

yearjournalcountryeditionlanguage
2019-02-01Medicina Oral Patología Oral y Cirugia Bucal
https://doi.org/10.4317/medoral.22959