A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis

6533b822fe1ef96bd127d943

RESEARCH PRODUCT

A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis

Vieta Eduard Patricia Vega Enrique Echeburúa Sara Barbeito Esther Lorente-rovira Jessica Fernández-sevillano Ana Luengo José Manuel Crespo Vicente Balanzá-martínez Ana González-pinto Ester Cerrillo Itxaso González-ortega Carlos Matute S. Alberich

subject

Psychosis medicine.medical_specialty animal structures Pronòstic mèdic Health Toxicology and Mutagenesis Psicosi Disease behavioral disciplines and activities Article law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Intervention (counseling)Internal medicine mental disorders medicine Scopus Humans Single-Blind Method first-episode psychosis Clinical treatment treatment Cognitive Behavioral Therapy business.industry Standard treatment R Public Health Environmental and Occupational Health Psychoses Cognition medicine.disease Prognosis Combined Modality Therapy 030227 psychiatry Clinical trial Treatment Adherence and Compliance early intervention Treatment Outcome Psychotic Disorders JCR Schizophrenia outcome Medicine Esquizofrènia business randomised controlled trial 030217 neurology & neurosurgery

description

Introduction: There is evidence that early intervention contributes to improving the prognosis and course of first-episode psychosis (FEP). However, further randomised treatment clinical trials are needed. Objectives: The aim of this study was to compare the efficacy of a combined clinical treatment involving Cognitive Behavioural Therapy (CBT) as an adjunctive to treatment-as-usual (TAU) (CBT+TAU) versus TAU alone for FEP. Patients and methods: In this multicentre, single-blind, randomised controlled trial, 177 participants were randomly allocated to either CBT+TAU or TAU. The primary outcome was post-treatment patient functioning. Results: The CBT+TAU group showed a greater improvement in functioning, which was measured using the Global Assessment Functioning (GAF) and Functioning Assessment Short Test (FAST), compared to the TAU group post-treatment. The CBT+TAU participants exhibited a greater decline in depressive, negative, and general psychotic symptoms

year	journal	country	edition	language
2021-07-06	International Journal of Environmental Research and Public Health

10.3390/ijerph18147239 http://europepmc.org/articles/PMC8304114